Humalog Pen Information
Learn about our convenient insulin pens, download step-by-step guides, and watch our injection tutorials.


Questions About Using KwikPen™
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What should my insulin look like?
Some insulins are cloudy while others are clear. Be sure to refer to the Patient Information inserts for the appearance of your specific insulin.

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Why should I use a new needle for each injection?
This will help ensure sterility. If needles are reused, you may get the wrong amount of insulin, a clogged needle, or a jammed Pen.

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What should I do if I am not sure how much insulin remains in my cartridge?
Hold the Pen with the needle end pointing down. The scale on the clear Cartridge Holder shows an estimate of the number of units remaining. These numbers should NOT be used for measuring an insulin dose.

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Why should I prime my KwikPen to a stream before each dose?
  1. Ensures that the Pen is ready to dose.
  2. Confirms that a stream of insulin comes out of the tip of the needle when you push the Dose Knob in.
  3. Removes air that may collect in the needle or insulin cartridge during normal use.
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What should I do if I cannot completely push in the Dose Knob when priming the KwikPen?
  1. Attach a new needle.
  2. Prime the Pen.
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What should I do if I see an air bubble in the cartridge?
You need to prime the Pen. Remember, do not store the Pen with the needle attached as this may cause air bubbles to collect in the insulin cartridge. A small air bubble will not affect your dose and you can continue to take your dose as usual.

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Why is it difficult to push the Dose Knob when I try to inject?
  1. Your needle may be clogged. Try attaching a new needle. When you do this you may see insulin come out of the needle. Then prime the Pen.
  2. Pressing the Dose Knob quickly may make the Dose Knob harder to push. Pressing the Dose Knob more slowly may make it easier.
  3. Using a larger diameter needle will make it easier to push the Dose Knob during your injection. See your healthcare professional to determine which needle size is best for you.
  4. If the Dose Knob continues to be difficult to push after following the steps above, try the steps below under "What should I do if my KwikPen is jammed?".
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What should I do if my KwikPen is jammed?
Your Pen may be jammed if it is difficult to inject a dose or dial a dose. To clear the jam:
  1. Attach a new needle. When you do this you may see insulin come out of the needle.
  2. Prime the Pen.
  3. Dial your dose and inject.
  4. If the Dose Knob is still difficult to push, contact the Lilly Answers Center at 1-800-Lilly-Rx (1-800-545-5979).
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Why is insulin leaking from the needle after I finished injecting my dose?
You may have removed the needle from your skin too quickly.
  1. Make sure you see a 0 in the Dose Window to confirm you received the complete dose.
  2. For the next dose, push and hold the Dose Knob in and count to 5 slowly before removing the needle.
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What should I do if my dose is dialed and the Dose Knob is accidentally pushed in without a needle attached?
  1. Dial back to zero.
  2. Attach a new needle. When you do this you may see insulin come out of the needle.
  3. Prime the Pen.
  4. Dial your dose and inject.
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What should I do if I dial a wrong dose (too high or too low)?
Turn the Dose Knob backward or forward to correct the dose before injecting.

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What should I do if I see insulin leaking from the KwikPen needle while dialing the dose or correcting the dose?
Do not inject the dose because you may not get your complete dose. Dial the Pen down to zero and prime the Pen again. Dial your dose and inject.

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What should I do if my full dose cannot be dialed?
The Pen will not allow you to dial a dose greater than the number of insulin units remaining in the cartridge. For example, if you need 31 units and only 25 units remain in the cartridge you will not be able to dial past 25. Do not attempt to dial past this point. You may either:
  1. Inject the partial dose and then inject the remaining dose using a new Pen, or
  2. Inject the full dose with a new Pen.
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Why can I not dial the dose to use the small amount of insulin that remains in my cartridge?
The Pen is designed to deliver at least 300 units of insulin. The Pen design prevents the cartridge from being completely emptied because the small amount of insulin that remains in the cartridge cannot be delivered.

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What should I do with used needles?
Most states require that you store used needles in a hard container. An empty liquid detergent bottle or sharps containers are good examples. You can buy sharps containers at most pharmacies. Check with your local health department to confirm the rules where you live.

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Humalog, Humalog Mix75/25, and Humalog Mix50/50 are available by prescription only. See Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information and the Pen User Manual enclosed in the Pen box for important facts about these products.

Important Safety Information
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with a longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog insulins are contraindicated during episodes of hypoglycemia and in patients sensitive to Humalog or one of its excipients. The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no clinical studies of the use of Humalog insulins in pregnancy or nursing mothers.

Potential side effects associated with the use of all insulins include low blood sugar, weight gain, low blood potassium, changes in fat tissue at the site of injection, and allergic reactions, both general and local. Humalog Mix75/25 and Humalog Mix50/50 should not be mixed with another insulin. Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog insulins are available by prescription only. See the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Product Information for important facts about these products.

Humalog is a registered trademark of Eli Lilly and Company. Humalog Mix75/25 and Humalog Mix50/50 are trademarks of Eli Lilly and Company.



Humalog Patient Information | Humalog Mix75/25 Patient Information | Humalog Mix50/50 Patient Information | Important Safety Information