Learn about our convenient insulin pens, download step-by-step guides, and watch our injection tutorials.
Questions About Using HumaPen® MEMOIR™
Glossary
Insulin
A hormone produced in the pancreas by beta cells, which is necessary for glucose (blood sugar) to be able to enter certain cells of the body and be used for energy.
A hormone produced in the pancreas by beta cells, which is necessary for glucose (blood sugar) to be able to enter certain cells of the body and be used for energy.
Glossary
Dose
The amount of a medicine to be taken within a given period.
The amount of a medicine to be taken within a given period.
- What should I do if the Pen does not turn on?
- What should I do if I want to turn the Pen off?
- What should I do if a part of the Pen display is missing or stays on all the time?
- What should I do if insulin does not come out when I prime the Pen?
- What should I do if there is an air bubble in the cartridge after I prime?
- What should I do if insulin comes out when I dial backwards?
- What should I do if the dose knob does not go to 0 when I inject my dose?
- What should I do if it is difficult to push down the dose knob when I try to inject?
- Why do I have to hold the injection button down for five seconds after the injection?
- What should I do with used needles?
What should I do if the Pen does not turn on?
Make sure you are pressing the ON button. If the Pen does not turn on, contact the Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or your healthcare professional.
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What should I do if I want to turn the Pen off?
To prevent your Pen from accidentally being turned off during an injection, there is no OFF button. Your Pen will not turn off unless the display is in READY MODE. The Pen will automatically turn off after 30 seconds of inactivity.
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What should I do if a part of the Pen display is missing or stays on all the time?
Your display is not working correctly. Do not use the Pen. Contact the Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or your healthcare professional.
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What should I do if insulin does not come out when I prime the Pen?
The needle may be clogged, the cartridge holder may not be completely screwed on, or the foot of the injection screw may not be against the cartridge plunger. You may not be able to see the foot of the injection screw, but repeating the priming step will move it to touch the plunger.
Priming until you see a stream of insulin will ensure that the foot of the injection screw is against the cartridge plunger.
- Repeat the priming steps until a stream of insulin is seen.
- If you do not see a stream of insulin after several attempts, attach a new needle.
- Repeat the priming steps until a stream of insulin is seen.
- If you are still unable to get insulin flowing out of the needle, do NOT use the Pen. Contact the Lilly Answers Center at 1-800-LillyRx (1-800-545-5979) or your healthcare professional.
What should I do if there is an air bubble in the cartridge after I prime?
Hold the Pen with the needle facing upwards and pointing away from your face. Tap the insulin cartridge holder gently with your finger so any air bubbles can collect near the top. Repeat the priming step. A small air bubble may remain in the cartridge after the completion of the priming step. If you have properly primed the Pen, this small air bubble will not affect your insulin dose.
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What should I do if insulin comes out when I dial backwards?
The dose knob may have been accidentally pushed when dialing backwards. To avoid this, do NOT push the dose knob when dialing backwards. Only push the dose knob when injecting.
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What should I do if the dose knob does not go to 0 when I inject my dose?
Your cartridge may not have had enough insulin for your entire dose. The number in the display window is the amount you did NOT receive. To get the rest of your dose: Dial down to 0. This will save the first injection in dose memory and return the Pen to READY MODE. Next, change the insulin cartridge, prime the Pen, and inject only the dose amount that you did not receive. Please note that your dose memory will record this as a separate dose.
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What should I do if it is difficult to push down the dose knob when I try to inject?
- Pressing the dose knob down quickly may make the button harder to push. Pressing the dose knob more slowly may make it easier.
- Pressing on the side of the dose knob may make it harder to inject. Be sure to press straight in on the dose knob.
- The force required to push the dose knob depends on the needle diameter. See your healthcare professional to determine which needle diameter is best for you.
- The dose knob may become harder to push if foreign material (dirt, dust), insulin, or other liquids get inside the Pen. Replace the Pen if the dose knob gets too hard to push.
Why do I have to hold the injection button down for five seconds after the injection?
After the injection button is fully depressed, it takes a few seconds to completely expel the insulin dose, primarily due to the elasticity of the rubber plunger. As with all Lilly insulin pens, five seconds is recommended as the appropriate time needed to ensure full dose delivery.
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What should I do with used needles?
Most states require that you store used needles in a hard container. An empty liquid detergent bottle or sharps containers are good examples. You can buy sharps containers at most pharmacies. Check with your local health department to confirm the rules where you live.
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Humalog is available by prescription only. See Humalog Patient Information for important facts about this product.
HumaPen MEMOIR is available by prescription only.
Important Safety Information
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with a longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.
Humalog insulins are contraindicated during episodes of hypoglycemia and in patients sensitive to Humalog or one of its excipients. The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no clinical studies of the use of Humalog insulins in pregnancy or nursing mothers.
Potential side effects associated with the use of all insulins include low blood sugar, weight gain, low blood potassium, changes in fat tissue at the site of injection, and allergic reactions, both general and local. Humalog Mix75/25 and Humalog Mix50/50 should not be mixed with another insulin. Starting or changing insulin therapy should be done cautiously and only under medical supervision.
Humalog insulins are available by prescription only. See the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Product Information for important facts about these products.
Humalog is a registered trademark of Eli Lilly and Company. Humalog Mix75/25 and Humalog Mix50/50 are trademarks of Eli Lilly and Company.
Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with a longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.
Humalog insulins are contraindicated during episodes of hypoglycemia and in patients sensitive to Humalog or one of its excipients. The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. Safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no clinical studies of the use of Humalog insulins in pregnancy or nursing mothers.
Potential side effects associated with the use of all insulins include low blood sugar, weight gain, low blood potassium, changes in fat tissue at the site of injection, and allergic reactions, both general and local. Humalog Mix75/25 and Humalog Mix50/50 should not be mixed with another insulin. Starting or changing insulin therapy should be done cautiously and only under medical supervision.
Humalog insulins are available by prescription only. See the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Product Information for important facts about these products.
Humalog is a registered trademark of Eli Lilly and Company. Humalog Mix75/25 and Humalog Mix50/50 are trademarks of Eli Lilly and Company.

























