Humalog is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Glucagon (Glucagon for Injection [rDNA origin]) is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).

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Control Throughout the Day

Mixture insulin like Humalog Mix75/25 and Humalog Mix50/50 can help provide blood sugar control throughout the day — at meals and in between. Good blood sugar control is an important step in managing your diabetes.

The rapid-acting insulin in Humalog Mix75/25 and Humalog Mix50/50 starts lowering blood sugar more quickly than regular human insulin, allowing for convenient dosing immediately before a meal (within 15 minutes). The longer-acting insulin in Humalog Mix75/25 and Humalog Mix50/50 provides blood sugar control between meals. How long the insulin works in your body may vary in different individuals or at different times in the same individual, based on dose, injection site, blood supply, and physical activity. Your healthcare provider will help set your goals and dose.

Available in a portable prefilled pen
Humalog Pen and Vial The Humalog^® Mix75/25™ KwikPen™ and Humalog^® Mix50/50™ KwikPen™ offer the convenience of a portable prefilled pen. These small, lightweight pens can be used just about anywhere — there is no refrigeration needed after first use so you don't have to worry about being near a fridge (discard 10 days after first use). Before use, patients are advised to carefully read the User Manual and Patient Information provided with the Pen.

Humalog (insulin lispro injection [rDNA origin]), Humalog Mix75/25 (75% insulin lispro protamine suspension, 25% insulin lispro injection [rDNA origin]), and Humalog Mix50/50 (50% insulin lispro protamine suspension, 50% insulin lispro injection [rDNA origin]) are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in these insulins.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog is an injectable, fast-acting insulin. Humalog Mix75/25 and Humalog Mix50/50 are a mixture of fast-acting and longer-acting insulins. These insulins start working faster than other insulins that contain regular human insulin. Humalog, Humalog Mix75/25, and Humalog Mix50/50 should be taken within 15 minutes before a meal. Humalog can be taken right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. The safety and effectiveness of Humalog Mix75/25 and Humalog Mix50/50 in patients less than 18 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog, Humalog Mix75/25, or Humalog Mix50/50 in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog, Humalog Mix75/25, and Humalog Mix50/50. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life-threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole body allergic reactions are less common, but may be life-threatening.

For other important information, see the Humalog, Humalog Mix75/25, and Humalog Mix50/50 Patient Information.

Humalog insulins are available by prescription only.

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Humalog^® is a registered trademark of Eli Lilly and Company and is available by prescription only.
Humalog^® Mix75/25™ and Humalog^® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.
HumaPen^® MEMOIR™ and HumaPen^® LUXURA™ HD are trademarks of Eli Lilly and Company and are available by prescription only.
Humalog^® KwikPen™, Humalog^® Mix75/25™ KwikPen™, and Humalog^® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.
Glucagon™ is a trademark of Eli Lilly and Company and is available by prescription only.