Humalog is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog, Humalog Mix75/25, and Humalog Mix50/50 are for use in patients with diabetes to control high blood sugar. Humalog should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Glucagon (Glucagon for Injection [rDNA origin]) is used to treat insulin coma or insulin reaction resulting from severe hypoglycemia (low blood sugar).

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Humalog in Insulin Pumps

Humalog is approved for use in external insulin pumps in adults with type 1 diabetes. Humalog lowers A1Cs compared to regular human insulin in adults with type 1 diabetes using an insulin pump.¹

An insulin pump is an external device that continuously delivers rapid-acting insulin to your body through a tiny tube placed under the skin. The insulin pump is about the size of a cell phone, and can be hidden under clothing or worn on your waistband.

Select Safety Information

When used in an external insulin pump, Humalog should not be diluted or mixed with any other insulin
Hypoglycemia is the most common adverse effect associated with insulins, including Humalog
Blood glucose monitoring is particularly important for patients using an external insulin pump

Humalog (insulin lispro injection [rDNA origin]) is for use in patients with diabetes to control high blood sugar and should be used with longer-acting insulin, except when used in combination with sulfonylureas in patients with type 2 diabetes.

Humalog should not be used during episodes of low blood sugar (hypoglycemia) or if you are allergic to anything in Humalog.

Important Safety Information
Starting or changing insulin therapy should be done cautiously and only under medical supervision.

Humalog is an injectable, fast-acting insulin. Humalog starts working faster than other insulins that contain regular human insulin. Take Humalog within 15 minutes before eating or right after eating a meal. Check your blood sugar levels as told by your healthcare professional.

If you have type 1 diabetes, you need to take a longer-acting insulin in addition to Humalog (except when using an external insulin pump). If you have type 2 diabetes, you may be taking diabetes pills and/or a longer-acting insulin in addition to Humalog.

The safety and effectiveness of Humalog in patients less than 3 years of age have not been established. There are no adequate and well-controlled clinical studies of the use of Humalog in pregnant or nursing women.

Low Blood Sugar
Low blood sugar is the most common adverse effect associated with insulins, including Humalog. Low blood sugar can happen suddenly, and symptoms may be different for each person and may change from time to time. Know your symptoms of low blood sugar. Severe low blood sugar can cause seizures and be life-threatening. Follow your healthcare professional's instructions for treating low blood sugar. Talk to your healthcare professional if low blood sugar is a problem for you.

Other Side Effects
Other potential side effects associated with the use of insulins include: low blood potassium, weight gain, changes in fat tissue at the injection site, and allergic reactions. Allergic reactions can happen at the site of injection and over the whole body. Whole body allergic reactions are less common, but may be life-threatening.

Pumps
When used in an external insulin pump, Humalog should not be diluted or mixed with any other insulin. Humalog administration in insulin pumps has not been studied in patients with type 2 diabetes. The infusion set and Humalog should be replaced and a new infusion site selected every 48 hours or less. Glucose monitoring is particularly important for patients using an external insulin pump. Humalog in the external pump should not be exposed to temperatures above 37°C (98.6°F).

Humalog was tested in the MiniMed^® Models 506, 507, and 508 insulin pumps using MiniMed^® Polyfin^® infusion sets.

Humalog was also tested in Disetronic^® H-TRONplus^® V100 insulin pump (with plastic 3.15 mL insulin reservoir), and the Disetronic D-TRON^® and D-TRONplus^® insulin pumps (with Humalog 3 mL cartridges) using Disetronic Rapid^® infusion sets. A Humalog 3 mL cartridge used in the D-TRON or D-TRONplus should be discarded after 7 days, even if it still contains Humalog. Infusion sets, D-TRON and D-TRONplus cartridge adapters, and Humalog in the external insulin pump reservoir should be discarded every 48 hours or less.

For other important information, see the Patient Information.

Humalog is available by prescription only.

Disetronic, H-TRONplus, D-TRON, and Rapid are registered trademarks of Roche Diagnostics GMBH.

Reference

Humalog Prescribing Information. Indianapolis, IN: Lilly USA, LLC; 2007.

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Humalog^® is a registered trademark of Eli Lilly and Company and is available by prescription only.
Humalog^® Mix75/25™ and Humalog^® Mix50/50™ are trademarks of Eli Lilly and Company and are available by prescription only.
HumaPen^® MEMOIR™ and HumaPen^® LUXURA™ HD are trademarks of Eli Lilly and Company and are available by prescription only.
Humalog^® KwikPen™, Humalog^® Mix75/25™ KwikPen™, and Humalog^® Mix50/50™ KwikPen™ are trademarks of Eli Lilly and Company and are available by prescription only.
Glucagon™ is a trademark of Eli Lilly and Company and is available by prescription only.